Backup is not the most important: It is restore.
Imagine that you make your backups regularly in multiple ways with at least one being offsite. One day you need the backup, but it does not work. You might have forgotten a directory, so you do not backup everything you think, you might have forgotten a password for an encrypted file or for some reason the automatic backup have not worked for the last 6 months.
Just as important as taking backup is to test that you can actually restore it. Try it on an old computer or when you get a new one. At least make sure that you can get up and running when necessary.